HUMAN INTESTINAL EPITHELIAL-CELLS RESPOND TO CRYPTOSPORIDIUM-PARVUM INFECTION WITH INCREASED PROSTAGLANDIN-H-SYNTHASE-2 EXPRESSION AND PROSTAGLANDIN-E-2 AND PROSTAGLANDIN-F2-ALPHA PRODUCTION

Authors
LAURENT F KAGNOFF MF SAVIDGE TC NACIRI M ECKMANN L
Citation
F. Laurent et al., HUMAN INTESTINAL EPITHELIAL-CELLS RESPOND TO CRYPTOSPORIDIUM-PARVUM INFECTION WITH INCREASED PROSTAGLANDIN-H-SYNTHASE-2 EXPRESSION AND PROSTAGLANDIN-E-2 AND PROSTAGLANDIN-F2-ALPHA PRODUCTION, Infection and immunity, 66(4), 1998, pp. 1787-1790
Citations number
25
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
66
Issue
4
Year of publication
1998
Pages
1787 - 1790
Database
ISI
SICI code
0019-9567(1998)66:4<1787:HIERTC>2.0.ZU;2-F
Abstract
Cryptosporidium parvum is an important cause of diarrhea in humans and several animal species. Prostaglandins play a central role in regulat ing intestinal fluid secretion in animal models of cryptosporidiosis, but their cellular sources and mechanisms of induction are unclear. He re, we show that C. parvum infection directly activates prostaglandin H synthase 2 expression and prostaglandin E-2 and F-2 alpha production in human intestinal epithelial cells.