BINDING TO HUMAN EXTRACELLULAR-MATRIX BY NEISSERIA-MENINGITIDIS

Authors
EBERHARD T VIRKOLA R KORHONEN T KRONVALL G ULLBERG M
Citation
T. Eberhard et al., BINDING TO HUMAN EXTRACELLULAR-MATRIX BY NEISSERIA-MENINGITIDIS, Infection and immunity, 66(4), 1998, pp. 1791-1794
Citations number
31
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
66
Issue
4
Year of publication
1998
Pages
1791 - 1794
Database
ISI
SICI code
0019-9567(1998)66:4<1791:BTHEBN>2.0.ZU;2-C
Abstract
Adhesion of Neisseria meningitidis strains to extracellular matrix (EC M) and purified matrix components was examined. Most strains bound to subendothelial ECM as well as to immobilized fibronectin and types I, III, and V collagen. Strains from healthy carriers adhered significant ly better than isolates from patients. The binding site was localized to the central 75-kDa cell-binding domain of the fibronectin molecule. This domain has not been described previously to interact with bacter ial structures.