Neospora caninum was found in fetal tissues of 34 of 688 cases of bovi
ne abortion submitted to the Pennsylvania Animal Diagnostic Laboratory
System during the period from May 1994 to November 1996. The aborted
fetuses ranged in gestational age from 3 to 8 months. Microscopic lesi
ons consisted primarily of encephalitis and myocarditis. A labeled (st
rept) avidin-biotin staining procedure using anti-N. caninum polyclona
l rabbit serum revealed N. caninum organisms within the fetal brain (2
7 of 27), heart (10 of 13), placenta (5 of 6), kidney (2 of 2), liver
(1 of 4) and skeletal muscle (1 of 1). (C) 1998 Elsevier Science B.V.