DICOPPER(II) COMPLEXES OF THE ANTITUMOR ANALOGS ACYLBIS(SALICYLALDEHYDE HYDRAZONES) AND CRYSTAL-STRUCTURES OF MONOMERIC [CU-2(1,3-PROPANEDIOYL BIS(SALICYLALDEHYDE ONE))(H2O)(2)]CENTER-DOT(CLO4)(2)CENTER-DOT-3H(2)O AND POLYMERIC [(CU-2(1,6-HEXANEDIOYL BIS(SALICYLALDEHYDE H)(2))(M)]CENTER-DOT(CLO4)(2M)CENTER-DOT-M(C2H5OH)

Salicylaldehyde hydrazones derived from acyldicarboxylic acids (H4Ln, where n = 0, 1, 2, 4, 6, 8, 10, 14 and is the number of methylene unit s) of varying chain length have been prepared, and their dicopper(II) complexes have been isolated as bis analogues of antitumor carboxylate hydrazones. The predominant structural form adopted is polymeric, wit h [{Cu2Ln}(m)] formed in neutral or basic solution, [{Cu-2(H2Ln)Cl-2}( m)] from dilute HCl, and [{Cu-2-(H2Ln)}(m)].(ClO4)(2m) from dilute HCl O4. The crystal structures of [Cu-2(H2L1)(H2O)(2)].(ClO4)(2) . 3H(2)O and [{Cu-2(H2L4)(C2H5OH)(2)}(m)].(ClO4)(2m). m(C2H5OH) have been deter mined. The structure of [Cu-2(H2L1)(H2O)(2)].(ClO4)(2) . 3H(2)O consis ts of discrete di-Cu(II) molecules with nonsymmetry-related Cu(II) cen ters. The copper atoms are square-planar with H2L1 supplying two tride ntate, monoanionic ONO domains and water completing the coordination s phere. The two metal-binding domains are inclined at 80 degrees to eac h other. For [{Cu-2(H2L4)(C2H5OH)(2)}(m)].(ClO4)(2m). m(C2H5OH) the sy mmetry-related copper atoms are square-pyramidal with the base compose d of H2L4, acting as a tridentate ONO chelator, and an O-bonded ethano l molecule. Axial phenolate bridges complete the coordination sphere, linking molecules to give a polymer. Compounds prepared have been char acterized by a range of physicochemical and spectroscopic techniques, and proton and metal ion stability constant data have been determined.