SYNTHESIS OF NEW BENZYLIC ESTERS OF OXIMES DERIVED FROM 1-PHENYL-PYRAZOLE COMPOUNDS

In the scope of a research program aiming at the synthesis and pharmac ological evaluation of new antithrombotic agents via rational molecula r design, we describe in this paper the synthesis of benzyl ethers of aryl-pyrazolic oxime derivatives. Ethers' (2a-2c) and (3a-3c) are deri ved from 4-formyl-1-N-phenylpyrazole (4) in good yield. Designed as in terphenylenic analogues of the ridogrel (1), one expects these compoun ds to present dual properties, i.e., thromboxane Az receptors antagoni sm and thromboxane synthetase inhibition.