STANDARDIZATION OF THE [N-15(2)]UREA URINE TEST METHOD TO DETECT ANTRAL HELICOBACTER-PYLORI INFECTION

335 [N-15(2)]urea examinations to detect gastric Helicobacter pylori i nfection were performed using a uniform study protocol broadened to ob tain a large quantity of various experimental data. The data were comp iled and assessed in order to establish the most suitable parameter fo r a standardized rest protocol. Second-hour urine following oral admin istration of the diagnostic agent was found to produce the dearest dis tinction between H. pylori-infected and non-infected persons. The thre shold value of c = 0.06 (the quotient of N-15(excess) abundance in uri nary ammonia and N-15(excess) abundance in the urinary urea) is not ag e-dependent. Though less suitable on its own, the N-15(excess) abundan ce of urinary ammonia is useful as a second parameter for interpreting the results in the case of c values slightly below 0.06. The standard ized test protocol is specified.