H. Ghaneolhosseini et al., SYNTHESIS OF NOVEL BORONATED ACRIDINES AND SPERMIDINES AS POSSIBLE AGENTS FOR BNCT, Tetrahedron, 54(15), 1998, pp. 3877-3884
An approach to synthesise three different boronated DNA-interacting co
mpounds (11, 15 gr 19) is described. Compound 11 is containing both an
acridine system and a spermidine residue. The acridine moiety would s
erve as DNA-intercalating fragment whereas the spermidine residue func
tions both as water-solubilising and DNA-interacting part 1,12-p-Carbo
ranyl bis[(N-3-aminopropyl, N-4-aminobutyl)-3-propane amide] hydrogen
chloride (15) was obtained by treating 13 first with ethyl chloroforma
te and then the secondary amine 2 Finally, 1, 12-Bis(N-(9-acridinyl)3-
aminopropyl)-p-carborane hydrogen chloride (19) was accomplished by hy
drochloronation of the corresponding free amine which was obtained by
the treatment of 18 with 9 in toluene/DMF. (C) 1998 Elsevier Science L
td. All rights reserved.