CHIRAL HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY RESOLUTION OF IBUPROFENESTERS

TWO cellulose-based chiral stationary phases (Chiralcel OD and Chiralc el OJ) were compared on their ability to resolve various aliphatic ibu profen esters. Chiralcel OJ with hexane as the mobile phase allows for the separation of most of the esters. Observed changes in resolution depending on the solute nature (basicity of the solute, esterified alc ohol chain length, presence of a double bond) are discussed. An exampl e of the application of this method for following the kinetic resoluti on of racemic ibuprofen is presented. Crown copyright (C) 1998 Publish ed by Elsevier Science B.V. All rights reserved.