GRANULOCYTE-COLONY-STIMULATING FACTOR DEMONSTRATES ANTITUMOR-ACTIVITYIN MELANOMA MODEL IN MICE

Granulocyte colony-stimulating factor (G-CSF) was found to exert antit umor activity against murine MmB16 melanoma when administered intratum orally. However, subcutaneous administration of this cytokine at a sit e distant from the growing tumor did not show any antitumor effects. G -CSF did not influence the: proliferative activity of MmB16 in vitro. Intraperitoneal administration of G-CSF resulted in decreased secretio n of nitric oxide (NO) by peritoneal macrophages and their decreased t umoricidal activity against MmB16.