SUCCESS OF INTRACYTOPLASMIC SPERM INJECTION IN COUPLES WITH MALE AND OR FEMALE CHROMOSOME-ABERRATIONS/

This paper reports on results of intracytoplasmic sperm injection (ICS I) in patients in whom constitutional or secondary chromosome aberrati ons were detected in the male and/or female partner, Out of 434 couple s treated by ICSI (590 cycles), 16 couples (3.7%) were affected by con stitutional chromosome aberrations and 96 (22.1%) by secondary chromos ome aberrations, Constitutional chromosome aberrations were found in e ight male and eight female patients, Couples with the aberration in th e male showed significantly lower fertilization, implantation and preg nancy rates (P < 0.05), The occurrence of female constitutional chromo some aberrations led to lower fertilization rates but implantation and pregnancy rates were similar to a control group; however, a higher ab ortion rate was noted, In the group with secondary chromosome aberrati ons, 22 males and 59 females carried an abnormality and in 15 couples, both partners, Compared to the remaining (unaffected) 322 couples, fe rtilization and embryo transfer rates were reduced but implantation ra tes and pregnancy rates were not different, In all couples where an ab ortion occurred, mainly parental autosomal aberrations were involved ( six out of eight), Our retrospective analysis shows that an unexpected ly high number of infertile couples in an ICSI programme are affected by chromosome fertilization rates observed in this subgroup of patient s.