SURFING ON A RETROGRADE WAVE - HOW DOES SHIGA TOXIN REACH THE ENDOPLASMIC-RETICULUM

Authors
JOHANNES L GOUD B
Citation
L. Johannes et B. Goud, SURFING ON A RETROGRADE WAVE - HOW DOES SHIGA TOXIN REACH THE ENDOPLASMIC-RETICULUM, Trends in cell biology, 8(4), 1998, pp. 158-162
Citations number
57
Categorie Soggetti
Cell Biology
Journal title
Trends in cell biology → ACNP
ISSN journal
09628924
Volume
8
Issue
4
Year of publication
1998
Pages
158 - 162
Database
ISI
SICI code
0962-8924(1998)8:4<158:SOARW->2.0.ZU;2-J
Abstract
Bacterial Shiga toxin and related toxins are endocytosed by higher euk aryotic cells. Tile toxin protein is then transported via the Golgi ap paratus to tile endoplasmic reticulum (ER) and into the cytosol, where it exerts its toxic effect. This review discusses current understandi ng of this retrograde transport pathway and how newly developed modifi ed toxins that allow detection and quantification of specific transpor t steps might prove useful teals in the future.