NEW KILOGRAM-SYNTHESIS OF THE ANTI-ALZHEIMER DRUG (-)-GALANTHAMINE

Authors
CZOLLNER L FRANTSITS W KUENBURG B HEDENIG U FROHLICH J JORDIS U
Citation
L. Czollner et al., NEW KILOGRAM-SYNTHESIS OF THE ANTI-ALZHEIMER DRUG (-)-GALANTHAMINE, Tetrahedron letters, 39(15), 1998, pp. 2087-2088
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
15
Year of publication
1998
Pages
2087 - 2088
Database
ISI
SICI code
0040-4039(1998)39:15<2087:NKOTAD>2.0.ZU;2-O
Abstract
A concise, scalable synthesis of(-)-galanthamine, a drug being used fo r the treatment of Alzheimer's disease, is described. The yield of the critical phenolic coupling step was optimized to 45-50%. For the redu ction of the aryl bromide, air-activated LiAlH4 was used and racemic n arwedine was converted to (-)-narwedine by a second order asymmetric t ransformation. (C) 1998 Elsevier Science Ltd. All rights reserved.