SOLID-PHASE C-ACYLATION OF ACTIVE METHYLENE-COMPOUNDS

Authors
SIM MM LEE CL GANESAN A
Citation
Mm. Sim et al., SOLID-PHASE C-ACYLATION OF ACTIVE METHYLENE-COMPOUNDS, Tetrahedron letters, 39(15), 1998, pp. 2195-2198
Citations number
30
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
15
Year of publication
1998
Pages
2195 - 2198
Database
ISI
SICI code
0040-4039(1998)39:15<2195:SCOAM>2.0.ZU;2-T
Abstract
Active methylene compounds were attached to the Wang resin by an ester linkage. C-acylation was achieved with a reactive species generated i n situ by the combination of a carboxylic acid, diethyl phosphorocyani date, and triethylamine. Cleavage from the resin with simultaneous dec arboxylation gave the products in moderate to good yield. (C) 1998 Els evier Science Ltd. All rights reserved.