SYNTHESIS OF ARYLPIPERAZINES VIA PALLADIUM-CATALYZED AROMATIC AMINATION REACTIONS OF BROMOARENES WITH N-TERT-BUTOXYCARBONYLPIPERAZINE

Authors
KERRIGAN F MARTIN C THOMAS GH
Citation
F. Kerrigan et al., SYNTHESIS OF ARYLPIPERAZINES VIA PALLADIUM-CATALYZED AROMATIC AMINATION REACTIONS OF BROMOARENES WITH N-TERT-BUTOXYCARBONYLPIPERAZINE, Tetrahedron letters, 39(15), 1998, pp. 2219-2222
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
15
Year of publication
1998
Pages
2219 - 2222
Database
ISI
SICI code
0040-4039(1998)39:15<2219:SOAVPA>2.0.ZU;2-Q
Abstract
Reaction of a series of bicyclic bromoarenes with N-tert-butoxycarbony lpiperazine (N-Boc-piperazine) under palladium-calalysed coupling cond itions followed by routine removal of the Boc group with trifluoroacet ic acid in dichloromethane gave the corresponding arylpiperazines in m oderate to good yield. (C) 1998 Elsevier Science Ltd. All rights reser ved.