C. Brefel et al., EFFECT OF FOOD ON THE PHARMACOKINETICS OF ROPINIROLE IN PARKINSONIAN-PATIENTS, British journal of clinical pharmacology, 45(4), 1998, pp. 412-415
Aims Ropinirole is a specific non-ergoline dopamine D-2-receptor agoni
st with antiparkinsonian properties. The pharmacokinetic parameters of
ropinirole taken in the fasted condition were compared with those whe
n it was co-administered with food. Methods This was an open, randomiz
ed, two sessions cross over study in 12 patients with Parkinson's dise
ase, comparing the steady-state pharmacokinetic profiles of ropinirole
on two different study days: 'fasted' and 'fed'. Results The mean C-m
ax was lower in the 'fed' regimen than in the 'fasted' one (-25%, P=0.
002). The median t(max) was observed 2.6 h later in the 'fed' regimen
than in the 'fasted' regimen (P<0.05). There was a slight but signific
ant decrease in AUC(0,8 h) in the 'fed' regimen (P=0.03). Conclusions
Food decreases the fate of absorption of ropinirole, but has little ef
fect on the extent of absorption.