CHARACTERIZATION OF AN INSULIN-LIKE-GROWTH-FACTOR (IGF) RECEPTOR AND THE INSULIN-LIKE EFFECTS OF IGF-1 IN THE BONY FISH, LATES-CALCARIFER

Authors
DRAKENBERG K CAREY G MATHER P ANDERSON A SARA VR
Citation
K. Drakenberg et al., CHARACTERIZATION OF AN INSULIN-LIKE-GROWTH-FACTOR (IGF) RECEPTOR AND THE INSULIN-LIKE EFFECTS OF IGF-1 IN THE BONY FISH, LATES-CALCARIFER, Regulatory peptides, 69(1), 1997, pp. 41-45
Citations number
30
Categorie Soggetti
Endocrynology & Metabolism",Physiology
Journal title
Regulatory peptides → ACNP
ISSN journal
01670115
Volume
69
Issue
1
Year of publication
1997
Pages
41 - 45
Database
ISI
SICI code
0167-0115(1997)69:1<41:COAI(R>2.0.ZU;2-S
Abstract
The present work is part of a broad phylogenetic study of the insulin superfamily of peptides in lower vertebrates. In the bony fish barramu ndi (Lates calcarifer), the presence of IGF receptors were investigate d in the liver by means of competitive binding studies. The results su ggested the presence of a type 1-like but no type 2-like IGF receptor. We also demonstrated insulin-like effects of intraperitoneally inject ed recombinant human (rh)-IGF-1 in barramundi with rh-ICF-l and rh-ins ulin showing similar effects with respect to induction of hypoglycemia and stimulation of incorporation of [C-14]-glucose into muscle glycog en. (C) 1997 Elsevier Science Ireland Ltd.