EFFECTS OF DAPHNODORIN-A, DAPHNODORIN-B AND DAPHNODORIN-C, NEW FLAVANS ISOLATED FROM TRADITIONAL CHINESE MEDICINE, ON THE 12-LIPOXYGENASE AND CYCLOOXYGENASE METABOLISM OF ARACHIDONIC-ACID IN RABBIT PLATELETS

Authors
SAKUMA S FUJIMOTO Y TSUNOMORI M TAGANO S NISHIDA H BABA K FUJITA T
Citation
S. Sakuma et al., EFFECTS OF DAPHNODORIN-A, DAPHNODORIN-B AND DAPHNODORIN-C, NEW FLAVANS ISOLATED FROM TRADITIONAL CHINESE MEDICINE, ON THE 12-LIPOXYGENASE AND CYCLOOXYGENASE METABOLISM OF ARACHIDONIC-ACID IN RABBIT PLATELETS, Prostaglandins, leukotrienes and essential fatty acids, 58(2), 1998, pp. 143-146
Citations number
26
Categorie Soggetti
Cell Biology",Biology,"Endocrynology & Metabolism
Journal title
Prostaglandins, leukotrienes and essential fatty acids → ACNP
ISSN journal
09523278
Volume
58
Issue
2
Year of publication
1998
Pages
143 - 146
Database
ISI
SICI code
0952-3278(1998)58:2<143:EODDAD>2.0.ZU;2-V
Abstract
The effects of daphnodorin A, B and C, isolated from the root and bark of Daphne odora THUNB, on the activities of 12-lipoxygenase and cyclo oxygenase in rabbit platelets were examined. Daphnodorin A and C were inhibitors of platelet 12-lipoxygenase and cyclooxygenase activities. Daphnodorin B had no effect on the two enzymatic pathways. The present data raise the possibility that daphnodorin A and C can be anti-throm botic and anti-atherosclerotic drugs through the suppressive influence on the platelet 12-lipoxygenase and cyclooxygenase.