PREVENTION OF SPONTANEOUS AND CHEMICALLY-INDUCED CARCINOGENESIS USINGACTIVATED CARBON-FIBER ADSORBENT - I. EFFECT OF THE ACTIVATED CARBON-FIBER ADSORBENT AQUALEN ON SPONTANEOUS CARCINOGENESIS AND LIFE-SPAN INMICE
Vn. Anisimov et al., PREVENTION OF SPONTANEOUS AND CHEMICALLY-INDUCED CARCINOGENESIS USINGACTIVATED CARBON-FIBER ADSORBENT - I. EFFECT OF THE ACTIVATED CARBON-FIBER ADSORBENT AQUALEN ON SPONTANEOUS CARCINOGENESIS AND LIFE-SPAN INMICE, Cancer letters, 126(1), 1998, pp. 23-28
Female SHR mice were fed the activated carbon fiber adsorbent Aqualen(
R) beginning at the age of 3 months through their life. Mice were fed
Aqualen five times per week together with lab chow at a daily dose of
100 mg/kg b.w. The addition of Aqualen into food did not significantly
influence the dynamics of body weight and the mean Life-span of the a
nimals. At the same time, the age at 90% mortality of mice was 4 month
s longer in the group exposed to Aqualen, There were no statistically
significant differences in the incidence of all tumors and malignant t
umors in the group of mice treated with Aqualen as compared with the c
ontrol group. However, in the group of mice exposed to Aqualen, there
was a 1.4 times reduction of the mean number of tumors per mouse. Feed
ing mice with the adsorbent led to a 3 months longer life-span in anim
als with any tumors and to a 5 months longer life-span in animals bear
ing malignant tumors (P < 0.05). No carcinogenic effect of Aqualen was
found. It could be supposed that Aqualen has some geroprotective and
anticarcinogenic properties. (C) 1998 Elsevier Science Ireland Ltd.