SYNTHESIS OF SOME NOVEL OXIME ETHER DERIVATIVES AND THEIR ACTIVITY INTHE BEHAVIORAL DESPAIR TEST

In this study, a new series of 2-aminoethyloxime ether derivatives of some aralkylketones was synthesized. Their structures have been elucid ated by UV, IR, H-1-NMR, C-13-NMR, mass spectra and elementary analysi s. These compounds were then screened for their inhibition of immobili ty as an indicator of possible antidepressant activities by using the 'behavioral despair test'. Results showed that all the new compounds d ecreased the immobility time, however, the inhibition observed with A0 3, A04 and H01 was significantly higher compared to fluvoxamine (p < 0 .01). (C) Elsevier, Paris.