ANTI-HU-ASSOCIATED PARANEOPLASTIC SENSORY NEUROPATHY WITH PERIPHERAL-NERVE DEMYELINATION AND MICROVASCULITIS

A patient had a paraneoplastic autonomic, then sensory, then sensory-m otor neuropathy with small cell lung carcinoma and a high titer Anti-H u antibody to nuclei of neuronal cells. As an unusual finding there wa s electrophysiological and pathological evidence of demyelination and a peripheral nerve microvasculitis. The relationship of microvasculiti s and peripheral nerve demyelination is discussed and their occurrence with paraneoplastic anti-Hu-associated sensory neuropathy is suggeste d not to be by chance. (C) 1998 Elsevier Science B.V.