PENICILLIN ACYLASE IN THE INDUSTRIAL-PRODUCTION OF BETA-LACTAM ANTIBIOTICS

Authors
BRUGGINK A ROOS EC DEVROOM E
Citation
A. Bruggink et al., PENICILLIN ACYLASE IN THE INDUSTRIAL-PRODUCTION OF BETA-LACTAM ANTIBIOTICS, Organic process research & development, 2(2), 1998, pp. 128-133
Citations number
60
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Organic process research & development → ACNP
ISSN journal
10836160
Volume
2
Issue
2
Year of publication
1998
Pages
128 - 133
Database
ISI
SICI code
1083-6160(1998)2:2<128:PAITIO>2.0.ZU;2-2
Abstract
Immobilized penicillin acylase is a biocatalyst suitable for the kinet ically controlled industrial synthesis of semi-synthetic antibiotics i n aqueous environments. Amoxicillin and ampicillin are obtained by con densing 6-aminopenicillanic acid with the amide or ester of D-(-)-4-hy droxyphenylglycine and D-(-)phenylglycine, respectively. Similarly, th e cephalosporin antibiotics cefadroxil and cephalexin can be obtained from 7-aminodesacetoxycephalosporanic acid.