Citation
A. Hansen et al., A HIERARCHICAL SCHEME FOR COOPERATIVITY AND FOLDING IN PROTEINS, Physica. A, 250(1-4), 1998, pp. 355-361
Citations number
11
Categorie Soggetti
Physics
Journal title
ISSN journal
03784371
Volume
250
Issue
1-4
Year of publication
1998
Pages
355 - 361
Database
ISI
SICI code
0378-4371(1998)250:1-4<355:AHSFCA>2.0.ZU;2-6
Abstract
We propose a protein model based on a hierarchy of constraints that fo
rce the protein to follow certain pathways when changing conformation.
The model exhibits a first-order phase transition, cooperativity and
is exactly solvable. It also shows an unexpected symmetry between fold
ing and unfolding pathways as suggested by a recent experiment. (C) 19
98 Elsevier Science B.V. All rights reserved.