Acne vulgaris may present in a wide variety of clinical forms dependin
g on the type, number and severity of the predominant lesion. Thus the
re may be mild, moderate or severe comedonal or inflammatory acne, the
latter with many subtypes. Furthermore, the number and extent of the
lesions do not necessarily predict the response to therapy, and patien
ts may also be catergorized as therapeutically responsive or therapeut
ically refractory. Finally, there may be alterations in the clinical m
anifestations and therapeutic response depending on the distribution o
f the lesions, age of the patient and provoking or complicating factor
s.