A NEW CONCEPT OF DRUG-DELIVERY FOR ACNE

Adapalene is a stable naphthoic acid derivative that displays a strong retinoid agonist pharmacology. This drug controls cell proliferation and differentiation, and possesses significant anti-inflammatory actio n. The retinoid action of adapalene are mediated by the ligand-activat ed gene transcription factors retinoic acid receptors RAR beta and RAR gamma. We describe here how an aqueous gel containing adapalene was s elected for the topical treatment of acne.