CLINICAL-APPLICATION OF 2 NOVEL RAPID BEDSIDE TESTS FOR THE DETECTIONOF CARDIAC TROPONIN-T AND CREATINE KINASE-MB MASS MYOGLOBIN IN WHOLE-BLOOD IN ACUTE MYOCARDIAL-INFARCTION

The objective of this study was to determine whether two novel rapid b edside assays for whole-blood detection of cardiac troponin T and crea tine kinase (CK)-MB mass/myoglobin could rule out or rule in acute myo cardial infarction in patients with acute chest pain. Ninety-two patie nts with chest pain <12 h prior to admission were investigated. No dif ference in the cumulative sensitivity of the TropT test and the CARDIA C STATus test (CK-MB mass and myoglobin in combination) was found 6 h after admission (94 vs. 97%), The cumulative positive predictive value of the TropT test and CARDIAC STATus test 6 h after admission was 97 and 76%, respectively. The negative predictive value was 97% for the T ropT test and 98% for the CARDIAC STATus test at this time point. Our data show that the rapid assays provide diagnostic as well as prognost ic information shortly after admission.