SYNTHESIS OF SOME ETHYL 2-ARYLAMINO-5-PHENYLTHIOTHIAZOLE-4-CARBOXYLATES AND THEIR SULFONES AS POTENTIAL ANALGESIC, ANTIINFLAMMATORY AND ANTIMICROBIAL AGENTS

Authors
BADDI MM MAHAJANSHETTI CS
Citation
Mm. Baddi et Cs. Mahajanshetti, SYNTHESIS OF SOME ETHYL 2-ARYLAMINO-5-PHENYLTHIOTHIAZOLE-4-CARBOXYLATES AND THEIR SULFONES AS POTENTIAL ANALGESIC, ANTIINFLAMMATORY AND ANTIMICROBIAL AGENTS, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 36(11), 1997, pp. 1074-1076
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry → ACNP
ISSN journal
03764699
Volume
36
Issue
11
Year of publication
1997
Pages
1074 - 1076
Database
ISI
SICI code
0376-4699(1997)36:11<1074:SOSE2>2.0.ZU;2-5
Abstract
Ethyl 2-arylamino-5-phenylthiothiazole-4-carboxylates 2a-f have been s ynthesised by nucleophilic displacement reaction of ethyl 2-arylamino- 5-bromothiazole-4-carboxylates 1a-f and thiophenoxide anion in boiling ethanol. Their corresponding sulphones 3a-f have been obtained by the oxidation of 2 with hydrogen peroxide in glacial acetic acid. Compoun ds 3a-f are found to possess good analgesic, antiinflammatory and fung icidal activities.