PROTECTIVE ROLE OF SUPEROXIDE-DISMUTASE IN IRON TOXICITY IN YEAST

Authors
WISNICKA R KRZEPILKO A WAWRYN J KRAWIEC Z BILINSKI T
Citation
R. Wisnicka et al., PROTECTIVE ROLE OF SUPEROXIDE-DISMUTASE IN IRON TOXICITY IN YEAST, Biochemistry and molecular biology international, 44(3), 1998, pp. 635-641
Citations number
17
Categorie Soggetti
Biology
Journal title
Biochemistry and molecular biology international → ACNP
ISSN journal
10399712
Volume
44
Issue
3
Year of publication
1998
Pages
635 - 641
Database
ISI
SICI code
1039-9712(1998)44:3<635:PROSII>2.0.ZU;2-G
Abstract
It has been found that yeast mutants deficient in cytosolic superoxide dismutase CuZnSOD are hypersensitive to ferrous iron. In contrast mut ants that are deficient in catalases and cytochrome c peroxidase do no t differ from the standard strain in this respect. These findings sugg est that iron toxicity may depend on the redox status of the cell. The y also shed light on the role of superoxide dismutases in preventing t he toxic effects of oxygen.