Localization of the pathological structures in relation to the surroun
ding anatomy and understanding of the surgical anatomy are probably th
e most important keys to successful neurosurgery. Image-guided surgery
is an important tool for understanding an individual's anatomy and fo
r precisely locating the lesion. Head registration is the most importa
nt step in image-guided surgery, required by every system in use today
, although these systems show great differences. In this study, head r
egistration techniques and user algorithms in 83 image-guided surgery
cases were analyzed. Several types of fiducials including skin markers
, bone fiducials, and the stereotactic frame were used for registratio
n. Clinical applications, ease of use, and computer-calculated accurac
y values for each type were compared. The average accuracy was 1.50 mm
. X-spot skin markers are the fiducials most commonly used with CT sca
n. The stereotactic frame was the most accurate method, with an accura
cy of 0.69 mm. Disc-shaped fiducials were used when MRI was the imagin
g modality; they provided an average accuracy of 2.62mm. Head registra
tion is an important part of image-guided surgery; the procedure used
for registration should be based on the requirements of each individua
l case. Our results indicated that the stereotactic frame is the most
accurate method of registration; however, skin markers provide reasona
ble accuracy with significant ease of use and patient comfort.