ACETOGENINS FROM ANNONA-GLABRA SEEDS

From the cytotoxic ethanol extract of Annona glabra seeds, a new mono- tetrahydrofuranic (mono-THF) acetogenin, glabranin, as well as pair of 22-epimer bis-THF acetogenins, were isolated by semipreparative HPLC. Four known mono-THF acetogenins with an identical threo/trans/threo r elative configuration, annonacin, annonacinone, corossolin and corosso lone, were found to be potent inhibitors of complex I of the mitochond rial respiratory chain. (C) 1998 Published by Elsevier Science Ltd. Al l rights reserved.