SYNTHESIS OF SUBSTITUTED CHIRAL PIPERAZONES RESEMBLING AZA-SUGARS

Authors
LOHSE A ERNHOLT BV BOLS M
Citation
A. Lohse et al., SYNTHESIS OF SUBSTITUTED CHIRAL PIPERAZONES RESEMBLING AZA-SUGARS, Acta chemica Scandinavica, 52(4), 1998, pp. 499-502
Citations number
11
Categorie Soggetti
Chemistry,Biology
Journal title
Acta chemica Scandinavica → ACNP
ISSN journal
0904213X
Volume
52
Issue
4
Year of publication
1998
Pages
499 - 502
Database
ISI
SICI code
0904-213X(1998)52:4<499:SOSCPR>2.0.ZU;2-T
Abstract
(6R)-6-(Hydroxymethyl)piperazin-2-one (1), (6S)-6-(hydroxymethyl)piper azin-2-one (2) and (6S)-6-[(1R, 2S, 3R)-1,2,3,4-tetrahydroxybutyl]pipe razin-2-one (3) have been prepared in optically pure forms starting fr om D-glucosamine hydrochloride (4). The compounds (1-3) were tested fo r glycosidase inhibition.