AN INTERFACIAL EQUILIBRIA MODEL FOR THE ELECTROKINETIC PROPERTIES OF A FAT EMULSION - PART III - A PREDICTIVE COMPUTER-MODEL

The semi-empirical thermodynamic model for the binding of metal ions t o an emulsion (intralipid 20%) reported previously (Hall et al., 1991; Gaskin et al., 1993) is incorporated into a thermodynamic computer mod el. This permits the zeta potential and emulsion stability together wi th precipitate formation to be estimated for any intravenous nutrition regimen. A regimen frequently used in the intravenous nutrition of pa tients is considered in this modeling study. The effect of solution pH and calcium on the zeta potential of the emulsion is predicted. Calci um and magnesium are the only metal cations which are predicted to be of importance when considering stability of this emulsion.