SEVERE ALLERGIC CONJUNCTIVITIS AND CHEMOSIS CAUSED BY DISODIUM-CROMOGLYCATE

A 63-year-old man with chronic, nonallergic rhinoconjunctivitis presen ted immediate adverse reactions, such as intense itching, burning, red ness and severe swelling of both conjunctivae after using disodium cro moglycate eye drops. Skin prick tests and conjunctival provocation tes ts were positive with pure disodium cromoglycate. Circulating IgE-spec ific antibodies to disodium cromoglycate in serum were demonstrated by RAST. We suggest that the acute ocular reaction was caused by disodiu m cromoglycate and that the underlying mechanism was probably an IgE-m ediated immunological reaction.