Dr. Boyd et al., DIOXYGENASE-CATALYZED CIS-DIHYDRODIOL FORMATION IN THE CARBOCYCLIC AND HETEROCYCLIC RINGS OF QUINOLINES, Chemical communications, (6), 1998, pp. 683-684
Evidence of enzyme-catalysed cis-dihydroxylation in the pyridine (3,4-
bond) and benzene rings (5,6- and 7,8-bonds) of quinoline and 2-substi
tuted quinolines is examined in light of the isolation of a heterocycl
ic cis-diol derivative of 2-quinolone, as a single enantiomer of oppos
ite absolute configuration to that found for the enantiopure carbocycl
ic cis-diol metabolites from quinolines.