DIOXYGENASE-CATALYZED CIS-DIHYDRODIOL FORMATION IN THE CARBOCYCLIC AND HETEROCYCLIC RINGS OF QUINOLINES

Authors
BOYD DR SHARMA ND CARROLL JG MALONE JF MACKERRACHER DG ALLEN CCR
Citation
Dr. Boyd et al., DIOXYGENASE-CATALYZED CIS-DIHYDRODIOL FORMATION IN THE CARBOCYCLIC AND HETEROCYCLIC RINGS OF QUINOLINES, Chemical communications, (6), 1998, pp. 683-684
Citations number
10
Categorie Soggetti
Chemistry
Journal title
Chemical communications → ACNP
ISSN journal
13597345
Issue
6
Year of publication
1998
Pages
683 - 684
Database
ISI
SICI code
1359-7345(1998):6<683:DCFITC>2.0.ZU;2-W
Abstract
Evidence of enzyme-catalysed cis-dihydroxylation in the pyridine (3,4- bond) and benzene rings (5,6- and 7,8-bonds) of quinoline and 2-substi tuted quinolines is examined in light of the isolation of a heterocycl ic cis-diol derivative of 2-quinolone, as a single enantiomer of oppos ite absolute configuration to that found for the enantiopure carbocycl ic cis-diol metabolites from quinolines.