RELATIONSHIP AMONG RISK-FACTORS OF ATHEROSCLEROSIS, LEUKOCYTE COUNT, AND SOLUBLE INTERCELLULAR-ADHESION MOLECULE-1

We investigated the effects of risk factors of atherosclerosis on solu ble intercellular adhesion molecule-1 (sICAM-1) concentration and leuk ocyte count by using multivariate statistical analysis, The subjects w ere 90 people who were hospitalized for a complete check-up examinatio n, Eight risk factors were selected as candidates for predictor variab les: age, body mass index (BMI), uric acid, glycohemoglobin A(1c), num ber of cigarettes smoked daily, total cholesterol, triglyceride, and h igh density lipoprotein (HDL)-cholesterol. The predictor variables wer e selected using a stepwise method, [criterion variable - predictor va riable (standardized regression coefficient)]; sICAM1-age (0.1859), nu mber of cigarettes (0.2558), triglyceride (0.2447); leukocytes-number of cigarettes (0.2827), triglyceride (0.2526), HDL-cholesterol (-0.280 0); stab leukocytes-number of cigarettes (0.2460); segmented leukocyte s-glycohemoglobin A(1c) (0.1495), number of cigarettes (0.2716), HDL-c holesterol (-0.3254); lymphocytes-BMI (0.2639), number of cigarettes ( 0.1495), triglyceride (0.3520); monocytes-glycohemoglobin A(1c) (0.261 7), These findings indicated that the risk factors of atherosclerosis may influence sICAM1 concentration and leukocyte count.