CELL-WALL ACTIVE ANTIFUNGAL COMPOUNDS PRODUCED BY THE MARINE FUNGUS HYPOXYLON OCEANICUM LL-15G256

Citation
D. Abbanat et al., CELL-WALL ACTIVE ANTIFUNGAL COMPOUNDS PRODUCED BY THE MARINE FUNGUS HYPOXYLON OCEANICUM LL-15G256, Journal of antibiotics, 51(3), 1998, pp. 296-302
Citations number
23
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology,"Biothechnology & Applied Migrobiology
Journal title
ISSN journal
00218820
Volume
51
Issue
3
Year of publication
1998
Pages
296 - 302
Database
ISI
SICI code
0021-8820(1998)51:3<296:CAACPB>2.0.ZU;2-K
Abstract
The cell wall targeted antifungal activity of Hypoxylon oceanicum LL-1 5G256 extracts resulted from the production of novel lipodepsipeptides and previously reported macrocyclic polylactones. In an optimized med ium, titers of the lipodepsipeptide and the polylactones reached appro ximately 200 similar to 400 mg/liter and 25 similar to 50 mg/liter, re spectively. The optimum fermentation temperature for production of 15G 256 gamma was 28 degrees C. Seawater appeared to have an inhibitory ef fect on metabolite accumulation at lower fermentation temperatures.