CELL-WALL ACTIVE ANTIFUNGAL COMPOUNDS PRODUCED BY THE MARINE FUNGUS HYPOXYLON OCEANICUM LL-15G256

The cell wall targeted antifungal activity of Hypoxylon oceanicum LL-1 5G256 extracts resulted from the production of novel lipodepsipeptides and previously reported macrocyclic polylactones. In an optimized med ium, titers of the lipodepsipeptide and the polylactones reached appro ximately 200 similar to 400 mg/liter and 25 similar to 50 mg/liter, re spectively. The optimum fermentation temperature for production of 15G 256 gamma was 28 degrees C. Seawater appeared to have an inhibitory ef fect on metabolite accumulation at lower fermentation temperatures.