CELL-WALL ACTIVE ANTIFUNGAL COMPOUNDS PRODUCED BY THE MARINE FUNGUS HYPOXYLON OCEANICUM LL-15G256 - II - ISOLATION AND STRUCTURE DETERMINATION

Fermentations of the marine fungus Hypoxylon oceanicum (LL-15G256) wer e found to have potent antifungal activity. Isolation and purification of the antifungal agents provided two classes of compounds, macrocycl ic polylactones and the lipodepsipeptides 15G256 gamma (1), 15G256 del ta (2) and 15G256 epsilon (3). The isolation and structure elucidation of the lipodepsipeptides, all containing D-glutamate, L-serine, and t he rare amino acid beta-ketotryptohan, are described in this paper.