EFFECT OF SAMPLE VOLUME LOCATION ON DOPPLER-DERIVED TRANSMITRAL INFLOW VELOCITY VALUES IN 288 NORMAL SUBJECTS 20 TO 80 YEARS OLD - AN ECHOCARDIOGRAPHIC, 2-DIMENSIONAL COLOR DOPPLER COOPERATIVE STUDY

The aims of the study were to evaluate in a population of 288 normal s ubjects 20 to 80 years old (1) the normal values of the indexes of the mitral how velocity pattern measured either at the tips of the mitral leaflets or at the annulus; (2) whether there was a significant diffe rence between the values obtained at the tips compared with those meas ured at the mitral annulus; (3) the correlation with aging between the indexes measured in the two different positions; and (4) whether cert ain physiological variables have different effects on diastolic functi on measured in the two different positions. The highest values were al ways measured at the tips of the mitral leaflets (p < 0.05); only atri al filling fraction, E acceleration time, and E deceleration velocity had higher values when measured at the level of annulus (p < 0.05). Th e A-wave peak velocity had the same mean value when measured at both t he tips and at the annulus. A significant difference in the correlatio n between parameters measured at the tips of the mitral leaflets with age and at the annulus (with age) was observed for the following param eters: (1) peak E velocity, E integral, total integral and E accelerat ion showed better correlation with age when measured at the annulus (p < 0.02); (2) peak A velocity and A integral showed better correlation with age when measured at the tips of the mitral leaflets (p < 0.001) . Multivariate analysis showed that age was the variable that had the most influence on diastolic function parameters; heart rate had less i nfluence on the diastolic function indexes.