Purpose: The authors examine the intermediate-term effects of adjuncti
ve intraoperative mitomycin C (MMC) in a cohort of patients who receiv
ed double-plate Molteno implants for complicated glaucomas. Methods: A
consecutive series of 21 patients who received MMC 0.5 mg/ml for 5 mi
nutes as an adjunct to a double-plate Molteno implant was compared by
life-table analysis to a historical control group of 18 patients who r
eceived either no adjunct or 5-fluorouracil (5-FU) but no MMC. Results
: At three years follow-up, 35% (95% confidence interval (CI), 15-57%)
of patients who received MMC avoided failure criteria of intraocular
pressure (IOP) less than 6 mm Hg or more than 21 mm Hg, addition of gl
aucoma medication, reoperation for glaucoma, or tube removal. Seventee
n percent (95% CI, 4-37%) of patients in the control group at three ye
ars follow-up met similar criteria (p = 0.039), No late complications
of tube erosion were seen in the MMC group. Conclusion: Intraoperative
MMC offers an increased likelihood of a two-to three-year period of m
edication-free IOP control in patients undergoing double-plate Molteno
implants, compared to similar patients receiving 5-FU or no adjunctiv
e antimetabolite therapy.