AUTOMATED PARALLEL SYNTHESIS OF CHALCONE-BASED SCREENING LIBRARIES

Authors
POWERS DG CASEBIER DS FOKAS D RYAN WJ TROTH JR COFFEN DL
Citation
Dg. Powers et al., AUTOMATED PARALLEL SYNTHESIS OF CHALCONE-BASED SCREENING LIBRARIES, Tetrahedron, 54(16), 1998, pp. 4085-4096
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
54
Issue
16
Year of publication
1998
Pages
4085 - 4096
Database
ISI
SICI code
0040-4020(1998)54:16<4085:APSOCS>2.0.ZU;2-R
Abstract
Using a variety of condensation and cyclization reactions, nine combin atorial arrays of individual chalcone derivatives, over 74,000 in all, were produced in 50 mu M quantities. The ease with which a broad rang e of diversity can be fabricated around a single molecular motif using automated parallel solution phase synthesis has been demonstrated. (C ) 1998 Published by Elsevier Science Ltd. All rights reserved.