THE ACTIVATED CORE APPROACH TO COMBINATORIAL CHEMISTRY - A SELECTION OF NEW CORE MOLECULES

Authors
PRYOR KE SHIPPS GW SKYLER DA REBEK J
Citation
Ke. Pryor et al., THE ACTIVATED CORE APPROACH TO COMBINATORIAL CHEMISTRY - A SELECTION OF NEW CORE MOLECULES, Tetrahedron, 54(16), 1998, pp. 4107-4124
Citations number
37
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
54
Issue
16
Year of publication
1998
Pages
4107 - 4124
Database
ISI
SICI code
0040-4020(1998)54:16<4107:TACATC>2.0.ZU;2-F
Abstract
Four new activated core molecules suitable for use in solution-phase c ombinatorial organic chemistry have been prepared. These molecules rep resent an attempt to further explore shape-space and increase the stru ctural diversity of prepared libraries, as well as to incorporate reco gnition elements in the cores to increase the chances for interaction with biological targets. Demonstrations of deconvolution strategies us ed to simplify complex libraries and build individual molecular specie s based on the cores are also provided. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.