SOLUTION-PHASE PARALLEL SYNTHESIS USING ION-EXCHANGE RESINS

Ion-exchange resins are useful as scavengers in solution-phase paralle l synthesis. Ester and amide libraries have been generated using basic ion-exchange resins to facilitate the formation of products and to re move reaction byproducts. Acidic ion-exchange resins have been used as selective amine scavengers in the synthesis of urea and amine librari es. Several compound libraries have been prepared using the basic ion- exchange resin Amberlyst 21 as part of our lead optimization program. The utility of ion-exchange resins as a means of generating both large and small focused libraries will be reviewed. (C) 1998 Published by E lsevier Science Ltd. All rights reserved.