The infrapatellar fat pad of Hoffa is an intracapsular structure that
is routinely visualized on magnetic resonance images of the knee. Beca
use disease in this region is not uncommon, it is important to be fami
liar with the various pathologic entities that may occur here, Abnorma
lities that: are intrinsic to this fat pad include Hoffa disease, intr
acapsular chondroma, localized nodular synovitis, postarthroscopy and
postsurgery fibrosis, and shear injury. In addition, the infrapatellar
fat pad may be involved secondarily from extrinsic processes, includi
ng articular disorders leg, joint effusion, intraarticular bodies, men
iscal cyst, ganglion cyst, cyclops lesion), synovial abnormalities leg
, pigmented villonodular synovitis; hemophilia synovial hemangioma; pr
imary synovial chondromatosis; chondrosarcoma; Lipoma arborescens; rhe
umatoid, seronegative, and septic arthritis; arthritis associated with
inflammatory intestinal disorders; synovitis associated with primary
osteoarthritis), and anterior extracapsular abnormalities. The approac
h to pathologic processes involving the infrapatellar fat pad of Hoffa
is simplified when one is familiar with regional anatomy and possible
differential diagnostic considerations.