ANTIPYRETIC, HYPOTHERMIC AND ANTIINFLAMMATORY ACTIVITIES AND METABOLITES FROM SOLANUM-LIGUSTRINUM LOOD

The acute toxicities of the global methanol extract of Solanum ligustr inum (Solanaceae) and the crude steroidal glycoalkaloids mixture were determined. The antipyretic, hypothermic and antiinflammatory activiti es of aqueous, global methanol, petroleum ether, dichloromethane and m ethanol extracts and crude steroidal glycoalkaloids mixture of the aer ial parts were evaluated. All the extracts and the crude steroidal gly coalkaloids mixture were inactive in the hypothermic activity assay, n evertheless, they showed antipyretic and antiinflammatory activities. Scopoletin and beta-sitosterol 3-O-beta-D-glucoside were isolated and identified from the dichloromethane extract. The impure coumarin fract ion showed antipyretic and antiinflammatory activities and beta-sitost erol glucoside exhibited antiinflammatory activity. In the light of th e results of several NOE experiments, the H-5 and H-8 signals in the H -1-NMR spectra of scopoletin were reassigned. The methanol global extr act yielded a crude steroidal glycoalkaloids mixture with antipyretic and antiinflammatory effects. (C) 1998 John Wiley & Sons, Ltd.