Magnetic resonance cholangiopancreatography (MRCP) is a noninvasive di
agnostic modality capable of producing high-quality images of the bili
ary tree and pancreatic duct. We evaluated the MRCP capability of depi
cting the normal pancreatic duct and, based on data achieved, studied
the usefulness in the pathologic pancreatic duct. MRCP was performed i
n 42 patients without any pancreatic lesion and in 162 patients with p
ancreatic diseases, including congenital anomalies of biliary tree and
pancreatic duct. Results were compared with endoscopic retrograde cho
langiopancreatography (ERCP) in 93 patients. The visualization of the
pancreatic duct and its branches and the presence or absence of dilata
tion, stenosis, and filling defects were recorded. All images were int
erpreted retrospectively and blindly by three radiologists. Among cont
rol patients, the main pancreatic duct (MPD) was depicted in the head,
body, and tail of the pancreas in 41 (98%), 39 (93%), and 31 (74%), a
nd accessory pancreatic duct and secondary branches in the head, body,
and tail of the pancreas were depicted in 11 (26%), eight (19%), four
(10%), and two (5%) of these patients. Compared with ERCP, MRCP overe
stimated the stenosis of MPD and underestimated the dilatation of the
branches and filling defects in the pancreatic duct in pancreatic dise
ases, especially pancreatitis. However, MRCP was distinctly advantageo
us over ERCP in diagnosing mucin-producing tumor of the pancreas, cyst
ic lesions, and depicting the whole, including the part distal to the
obstructed site. Four of the eight cases of pancreas divisum, and 10 o
f the 12 cases of anomalous pancreaticobiliary duct union also were de
monstrated. MRCP can accurately demonstrate the normal pancreatic duct
as well as various pancreatic duct abnormalities, including congenita
l anomalies of the biliary tree and pancreatic duct.