SYNTHESIS OF A CLATHRATE HOST FOR FORMAMIDES, 5-DINITROBENZOYLAMINO)-6-METHYLPHENYL]PHTHALIMIDE, AND ANALYSIS OF THE INTERACTIONS IN THE HOST-GUEST COMPLEX

A clathrate host, ,5-dinitrobenzoylamino)-6-methylphenyl]phthalimide 1 is designed to achieve inclusion of N-substituted formamides. N,N-Dia lkylformamides HCONR2 of various sizes 2a-e [2a: R = Me; 2b: R = Et; 2 c: R = Pr-i; 2d: R-2 = -(CH2)(5)-, 2e: R-2 = -(CH2)(2)O(CH2)(2)-] and dimethyl sulfoxide have been included as the guests in a clathrate hos t 1, in the ratio 1 :1 in each case. The interaction between the host and guest has been investigated by X-ray analysis of complex 1 2e (1 : 1). The phthalimide plane and the N-phenyl group are orthogonal, whic h makes a suitable space for recognition of the formamides.