COMPUTER-ASSISTED DESIGN OF NOVEL LEUKOTRIENE C-4 RECEPTOR ANTAGONISTS

Authors
RAMAA CS KULKARNI VM
Citation
Cs. Ramaa et Vm. Kulkarni, COMPUTER-ASSISTED DESIGN OF NOVEL LEUKOTRIENE C-4 RECEPTOR ANTAGONISTS, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 36(12), 1997, pp. 1160-1163
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry → ACNP
ISSN journal
03764699
Volume
36
Issue
12
Year of publication
1997
Pages
1160 - 1163
Database
ISI
SICI code
0376-4699(1997)36:12<1160:CDONLC>2.0.ZU;2-5
Abstract
Structural features of the agonist leukotriene C-4 (LTC4) derived from conformational analysis has led to the development of an intuitive re ceptor model and the design of potential LTC, antagonists. These compo unds are modelled, in which either phenoxymethyleneoxadiazole, N-pheny lbenzamide or phenyloxymethylenetetrazole functionality is incorporate d as a planar equivalent of LTC4. The trifluoromethyl group is introdu ced at the lipophilic binding pocket of the agonist.