SYNTHESES OF 1,5-BENZOTHIAZEPINES - PART XIX - SYNTHESES OF 10-SUBSTITUTED BENZOPYRANOBENZOTHIAZEPINES AS PROSPECTIVE CARDIOVASCULAR AGENTS

Authors
UPRETI M PANT S DANDIA A PANT UC
Citation
M. Upreti et al., SYNTHESES OF 1,5-BENZOTHIAZEPINES - PART XIX - SYNTHESES OF 10-SUBSTITUTED BENZOPYRANOBENZOTHIAZEPINES AS PROSPECTIVE CARDIOVASCULAR AGENTS, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 36(12), 1997, pp. 1185-1188
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry → ACNP
ISSN journal
03764699
Volume
36
Issue
12
Year of publication
1997
Pages
1185 - 1188
Database
ISI
SICI code
0376-4699(1997)36:12<1185:SO1-PX>2.0.ZU;2-A
Abstract
stituted-2-chloro-6a,7-dihydro-6H-7-(4-substituted phenyl)-6-phenyl-[1 ]benzopyrano[3,4-c] [1,5] benzothiazepines 3a-l have been synthesized by reacting (E)-6-chloro-3- (4-chloro/methoxybenzylidene) flavanones 2 a, b with 5-substituted-2-aminobenzenethiols 1a-f by reflux heating in dry toluene containing piperidine (1:1). The products have been teste d for purity by TLC and microestimation of nitrogen. IR and H-1 NMR an d mass spectral studies have enabled the assignment of structures. Bio assay screening of 3e,f,h and i show mild analgesic and anticonvulsant activity.