Aims. To find a pre-operative test for nipple and areola involvement i
n breast cancer. Methods. Areola-tumour distance was measured in 140 c
onsecutive patients (median age 45, range: 23-83) undergoing a mastect
omy. We analysed whether nipple and areola correlated with areola-tumo
ur distance, tumour size, nodal status, perinodal involvement and lymp
hatic embolization. Results. The nipple was involved in 22 (16%) cases
and this correlated with tumour size, number of lymph nodes, perinoda
l extension and presence of lymphatic emboli. In all these 22 cases, t
he tumour was within 2.5 cm of the areola. Tumour size, however, could
not predict nipple involvement in tumours within 2.5 cm of the areola
r edge. Conclusions. In the one-fifth of cases where the tumour is ove
r 2.5 cm from the areola, preserving the nipple and areola for reconst
ruction may be worthwhile. In remaining cases, some other predictive t
est for nipple involvement would be necessary.