Since 1981 long-term oxygen therapy (LTOT) has become an important pro
cedure for the rehabilitation of patients with chronic respiratory ins
ufficiency in Switzerland too. As a result of long-term clinical exper
ience as well as technical progress, there is, however, increasing nee
d for an updated reassessment of guidelines and standardized managemen
t respectively: the indications for LTOT - so far restricted to patien
ts with COPD - are extended to patients with pulmonary diseases other
than COPD associated with chronic hyperemia (pO(2) <7.3 kPa) provided
there is enough evidence of clinical benefit. Another important aspect
of LTOT focusses on the appropriate application of different oxygen s
ources. Oxygen concentrators are still accepted to be the most economi
c domiciliary source. For shortterm outdoor activities, small portable
cylinders in combination with an oxygen conserving system should be u
sed. However, in regular mobile oxygen therapy liquid oxygen is the be
st choice, generally consisting of a domiciliary reservoir and portabl
e canisters. Delivery of oxygen through a transtracheal catheter is su
perior to nasal cannula because of lower oxygen consumption, decreased
breathing work and improved compliance respectively. To organize and
follow-up LTOT in Switzerland, a very efficient concept was introduced
many years ago which is characterized by economical cooperation betwe
en physicians, insurances, technical suppliers and social providers. T
oday more than 3000 patients corresponding to 38/100 000 inhabitants b
enefit from LTOT. Future perspectives should target an earlier start t
o continuous as well as mobile LTOT, in order to improve rehabilitatio
n in still active conditions instead of merely palliating the terminal
stages.