CREUTZFELDT-JAKOB-DISEASE WITH FEATURES OF OBSESSIVE-COMPULSIVE DISORDER AND ANOREXIA-NERVOSA - THE ROLE OF CORTICAL-SUBCORTICAL SYSTEMS

Citation
Ol. Lopez et al., CREUTZFELDT-JAKOB-DISEASE WITH FEATURES OF OBSESSIVE-COMPULSIVE DISORDER AND ANOREXIA-NERVOSA - THE ROLE OF CORTICAL-SUBCORTICAL SYSTEMS, Neuropsychiatry, neuropsychology, and behavioral neurology, 10(2), 1997, pp. 120-124
Citations number
49
Categorie Soggetti
Clinical Neurology
ISSN journal
0894878X
Volume
10
Issue
2
Year of publication
1997
Pages
120 - 124
Database
ISI
SICI code
0894-878X(1997)10:2<120:CWFOOD>2.0.ZU;2-B
Abstract
The authors examined the clinical and neuropathological characteristic s of a patient who developed features of obsessive-compulsive disorder (OGD) and anorexia nervosa (AN) as the initial presentation of Creutz feldt-Jakob disease. He had mild Parkinsonism and showed deficits in v isual scanning, set shifting, graphomotor speed, sequencing, and verba l and nonverbal memory. Neuropathological study showed spongiosis and neuronal loss in cortical (e.g., frontal, temporal, parietal), and esp ecially in subcortical structures (e.g., basal ganglia, thalamus). Thi s study supports the hypothesis of abnormal frontal-striatal functioni ng in the cause of OCD, even in demented subjects. In addition, the au thors discuss the rule of frontal-temporal-subcortical dysfunction in the cause of acquired AN.