Ol. Lopez et al., CREUTZFELDT-JAKOB-DISEASE WITH FEATURES OF OBSESSIVE-COMPULSIVE DISORDER AND ANOREXIA-NERVOSA - THE ROLE OF CORTICAL-SUBCORTICAL SYSTEMS, Neuropsychiatry, neuropsychology, and behavioral neurology, 10(2), 1997, pp. 120-124
The authors examined the clinical and neuropathological characteristic
s of a patient who developed features of obsessive-compulsive disorder
(OGD) and anorexia nervosa (AN) as the initial presentation of Creutz
feldt-Jakob disease. He had mild Parkinsonism and showed deficits in v
isual scanning, set shifting, graphomotor speed, sequencing, and verba
l and nonverbal memory. Neuropathological study showed spongiosis and
neuronal loss in cortical (e.g., frontal, temporal, parietal), and esp
ecially in subcortical structures (e.g., basal ganglia, thalamus). Thi
s study supports the hypothesis of abnormal frontal-striatal functioni
ng in the cause of OCD, even in demented subjects. In addition, the au
thors discuss the rule of frontal-temporal-subcortical dysfunction in
the cause of acquired AN.